Strictly from a chemical structure perspective, whether it is created synthetically or derived naturally both are identical. However, when it is from a natural source, it is rarely just purified caffeine. For example, caffeine derived from green tea, will also most likely include other naturally-occurring components. In this case, it will include antioxidant polyphenols and L-theanine. The powerful antioxidants in green tea help support and protect a healthy cardiovascular system and other cellular structures throughout the body. These unique antioxidants can also help boost the body's metabolism. Green tea also contains L-theanine. This unique amino acid supports cognitive function and boosts clarity of mind, especially when combined with caffeine. L-theanine can promote the production of alpha brain waves, which can influence the creative functions of the mind. Caffeine by itself does not offer these benefits.
Compare synthetic caffeine or naturally-occurring caffeine to listening to a symphony. Imagine a symphony with only one instrument playing. While it might be interesting to listen to 100 violins, it is even better when the symphony consists of a combination of many different instruments. A typical symphony orchestra is made of strings, woodwinds, brass and percussion. Like a symphony made of many instruments, natural sources of caffeine are a combination of many components that work together in concert with one another. This combination offers a broader array of benefits and is believed to be safer when used in its natural state as part of a whole.*
